Peptic ulcer disease was once being
recognized as a complicated disease which can turn out to be life threatening.
For more than a century, it was often being treated surgically, with resulting
high morbidity and mortality rate. The
perception of the pathophysiology of peptic ulcer disease has totally changed
during the 1980s, when Barry J. Marshall and J. Robin Warren discovered the
relationship between helicobacter pylori with gastritis and gastric ulcer.
Since then, the management of peptic ulcer disease has been shifted towards
conservative treatment with various pharmacological therapy being introduced to inhibit the gastric acid
secretions and to eradicate the H.pylori J. Marshall and J. Robin Warren were
being awared the 2005 Nobel prize for their contribution.
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